In real-life, Mayim began life as a child actress, with roles in MacGyver and Blossoms, but took a break from acting to study for a doctorate in neuroscience. Mayim Bialik joined the cast in season three as neuroscientist Amy. Simon Helberg started his career in a comedy duo Mayim Bialik as Amy Farrah Fowler
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Before The Big Bang Theory, he appeared on the sketch comedy series MADtv as well as Sabrina the Teenage Witch and Arrested Development. Playing Howard is Simon Helberg, who started his career as one part of a comedy duo with Drunk History creator Derek Waters. Kunal Nayyar plays Raj Simon Helberg as Howard Wolowitz While his only television credit prior to The Big Bang Theory is a small role on NCIS, he gained attention for his role in the play Huck & Holden, where he portrayed an Indian exchange student. While studying business at university, Kunal took an interest in acting and found work doing American television ads and plays. Hapless Raj is played by Indian actor Kunal Nayyar. Kaley Cuoco began acting as a child Kunal Nayyar as Raj Koothrappali Not long after, she was cast on the sitcom Ladies Man and The Brady Bunch film Growing Up Brady. Like her co-star Johnny, she also started acting as a youngster and was cast at the age of 10 to play a young Karin Carter in the 1995 action thriller Virtuosity. Kaley Cuoco takes on the role of Leonard and Sheldon's neighbour, Penny. Jim Parsons played minor roles before landing The Big Bang Theory Kaley Cuoco as Penny One of his earliest roles that caught the attention of viewers was in an advert for Quiznos. He relocated to New York in his early twenties to pursue a career in acting and secured a few minor roles before landing the part on the sitcom. Jim Parsons was born and raised in Texas, just like his character, the awkward but lovable Sheldon Cooper. MORE: See the Big Bang Theory cast and their real-life families Jim Parsons as Sheldon Cooper MORE: See inside The Big Bang Theory star Kunal Nayyar's beautiful LA home As a kid, he also starred in National Lampoon's Christmas Vacation and the series Blossoms and American Dreamer. Johnny landed his first acting gig aged 7 when he was cast in CBS miniseries Murder Ordained. Leonard is the glue that holds the gang together and is played by actor Johnny Galecki. WATCH: Are you a fan of The Flight Attendant? Johnny Galecki as Leonard Hofstadter
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